What Makes Gamma Tocopherols so Important?
Vitamin E activity doesn't come from one single molecule, but from a family of related molecules called tocopherols and tocotrienols. There are four tocopherols (alpha, beta, gamma, and delta) and four tocotrienols (alpha, beta, gamma, and delta), of which only alpha-tocopherol was recognized in the 1960s, by the government, to have Vitamin E activity, which is measured in International Units (I.U.s).
Because of that decision only the alpha-tocopherol portion of a Vitamin E product is considered "Vitamin E," so, the I.U. content of Vitamin E supplements generally refers to only alpha-tocopherol. But recent research shows that the whole family of Vitamin E isomers provides valuable health benefits. New findings about Gamma Tocopherols are especially intriguing.*
Each softgel of UNIQUE E® Mixed Tocopherols Concentrate contains a minimum of 300mg of d-gamma tocopherol.
Gamma Tocopherol is part of the Vitamin E family and has both antioxidant and non-antioxidant functions in the human body.
Recent research suggests that:
Unlike other Vitamin E supplements that provide little to no d-gamma tocopherol, UNIQUE E® provides a powerful 300mg of d-gamma tocopherol in every softgel. While researchers and marketers alike have only recently recognized the importance of d-gamma tocopherol, our customers know that A.C. Grace Company has proclaimed the importance of d-gamma tocopherol since 1962! Vitamin E is a complex of molecules that work together synergistically. UNIQUE E® Mixed Tocopherols is a specialized proprietary formula of concentrated tocopherols specifically designed to provide the highest biological activity and maximum synergistic benefits of the all-natural complex.*
The NATURAL formula contained in UNIQUE E® is High in GAMMA and High in ALPHA content because we know the two isomers work closely together in the human body. Then we add a proprietary amount of each of the DELTA and BETA isomers to provide a full-complex of the four tocopherol isomers as they work synergistically together in the body, just as in nature.
1 - Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN; gamma-tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis -- Jiang Q, Wong J, Ames BN; [gamma]-tocopherol induces apoptosis in androgen-responsive LNCaP Prostate Cancer Cells via Caspase-Dependent and Independent Mechanisms.
2 - Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K; gamma-tocopherol up-regulates peroxisome proliferator activated receptor (PPAR) gamma expression in SW 480 human colon cancer cell lines.
3 - Jiang Q, Ames BH; gamma-tocopherol but not alpha-tocopherol, decreases pro-inflammatory eicosanoids and inflammation damage in rats. -- Jiang Q, Elson-Schwab I, Courtemanche C, Ames BN; gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells.
4 - Handelman GJ, Machlin LJ, Fitch K, Weiter JJ, Dratz EA; oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans. Journal of Nutrition 1985 Jun;115(6):807-13.