Available in two sizes — 120-softgel and an "easy travel size" 30-softgel bottle.
Each 700mg beef softgel contains the highest concentration of the complete Vitamin E tocopherol complex — HIGH-Gamma, HIGH-Alpha, with Beta and Delta isomers — completely void of fillers or additives that can turn rancid. This all-natural, PURE Vitamin E concentrate consists of the natural form of Vitamin E as obtained through the diet and as used by the body.
Vitamin E is a complex of eight molecules that work together synergistically. Taking a Vitamin E supplement with only d-alpha tocopherol instead of the entire mixed tocopherols family of isomers can actually deplete the level of d-gamma tocopherol in the body.
The mainstream medical community only recently recognized the importance of d-gamma tocopherol. But A.C. Grace has noted the importance of d-gamma tocopherol since 1962. Our proprietary formula of concentrated tocopherols is specifically designed to provide the highest biological activity and maximum synergistic benefits of the all-natural complex.
Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K; gamma-tocopherol up-regulates peroxisome proliferator activated receptor (PPAR) gamma expression in SW 480 human colon cancer cell lines.
Handelman GJ, Machlin LJ, Fitch K, Weiter JJ, Dratz EA; oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans. Journal of Nutrition 1985 Jun;115(6):807-13.
Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN; gamma-tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis -- Jiang Q, Wong J, Ames BN; [gamma]-tocopherol induces apoptosis in androgen-responsive LNCaP Prostate Cancer Cells via Caspase-Dependent and Independent Mechanisms.
Jiang Q, Ames BH; gamma-tocopherol but not alpha-tocopherol, decreases pro-inflammatory eicosanoids and inflammation damage in rats. -- Jiang Q, Elson-Schwab I, Courtemanche C, Ames BN; gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells.
Unlike other fat soluble vitamins, vitamin E is NOT accumulated in the liver. This astonishing fact was recently proven in a paper entitled, Vitamin E Trafficking (see references below). The authors report, “the liver does not accumulate ‘toxic’ amounts of vitamin E. Excess vitamin E is not accumulated in the liver, but is excreted, mostly in bile, via a p-glycoprotein (ABCB4)-mediated process.” Speak with your primary health care provider to determine a dosage that is appropriate for your health goals.*
Ann. N.Y. Acad. Sci. 1031: 1–’D012 (2004). doi: 10.1196/annals.1331.001 Vitamin E Trafficking Maret G. Trabera, Graham W. Burtonb and Robert L. HamiltoncaLinus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA; bOccell, Inc., Ottawa, Ontario K1B 5B0, Canada; cDepartment of Anatomy, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
Kappus H, Diplock AT. Tolerance and safety of vitamin E: a toxicological position report. Free Radic Biol Med 1992;13:55–’D074.
Vitamins E and C are safe across a broad range of intakes. Hathcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B, Jialal I, Johnston CS, Kelly FJ, Kraemer K, Packer L, Parthasarathy S, Sies H, Traber MG. Am J Clin Nutr. 2005 Apr;81(4):736-45.